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Peripheral Odontogenic Keratocysts (POKCs) are rare, extraosseous manifestations of odontogenic keratocysts, often found in the buccal mucosa and gingiva. This video explores the clinical features, diagnostic methods, and treatment strategies for POKCs, including the importance of microscopic excision to prevent recurrence. We delve into two detailed case studies from Beijing Stomatological Hospital, highlighting the challenges in managing these cysts due to their soft tissue location and adherence to surrounding structures. The video also reviews the literature, discussing the recurrence rates, treatment modalities, and the role of surgical microscopes in improving surgical outcomes. Learn about the correlation between POKCs and Gorlin-Goltz syndrome, and why extended follow-up periods are crucial for patient monitoring. This comprehensive overview is essential for dental professionals and patients seeking to understand the complexities of POKCs and the latest in their management.