Acute Myeloid Leukemia AML with recurrent genetic abnormalities ; Definition, Causes, symptoms скачать в хорошем качестве

Acute Myeloid Leukemia AML with recurrent genetic abnormalities ; Definition, Causes, symptoms

Acute Myeloid Leukemia (AML) with recurrent genetic abnormalities is a subtype of AML characterized by specific chromosomal and molecular changes that significantly impact its diagnosis, prognosis, and treatment. These abnormalities are classified under the World Health Organization (WHO) and International Consensus Classification (ICC) systems2. Common Genetic Abnormalities Chromosomal Translocations: t(8;21): RUNX1-RUNX1T1 fusion gene, associated with favorable prognosis. inv(16) or t(16;16): CBFB-MYH11 fusion gene, also linked to favorable outcomes. t(15;17): PML-RARA fusion gene, defining acute promyelocytic leukemia (APL). Gene Mutations: NPM1: Frequently found in cytogenetically normal AML and associated with favorable prognosis. FLT3-ITD: Linked to poor prognosis, especially with high allelic ratios. CEBPA: Biallelic mutations are associated with favorable outcomes. Clinical Implications These genetic abnormalities guide risk stratification and treatment decisions. For example: Favorable-risk AML may be treated with standard chemotherapy. High-risk AML often requires targeted therapies, such as FLT3 inhibitors, or stem cell transplantation #Leukemia