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Join Dr. Chat Perche, MD, PhD, for a high-speed study session. This video is designed so that by the time you finish watching, you'll have perfectly memorized the frequently asked exam topics. By the end of this video, you'll have perfectly memorized about 5-FU. It masquerades as Uracil, and induces damage to DNA. Do you want to know the mechanism of action? Elevate your understanding of 5-Fluorouracil (5-FU) with my updated YouTube video! 🎥🔬 In this enhanced version, I provide a deeper exploration of 5-FU as a pyrimidine analogue disrupting DNA synthesis. Ace your exams by understanding the core concepts without unnecessary complexities. Watch now and boost your knowledge efficiently! 📚✨ #5FU #pharmacologylectures #anticancer 【Notes】 ▹This video was created based on data as of January 2024, with the purpose of supporting medical students in their exam preparations. ▹Please note that thanks to the tireless efforts of researchers worldwide, this data is updated daily. ▹Unauthorized reproduction is prohibited. 【Contents】 00:00 5-FU: an antimetabolite that mimics uracil 01:20 5-FU: the mechanism of action, operating as a mimic, emulating the functions of uracil. 02:58 5-FU funcitions in S phase of cell cycle. 【Reference and figure】 I express my gratitude and respect for your wonderful achievements. 1. Longley, D., Harkin, D. & Johnston, P. 5-Fluorouracil: mechanisms of action and clinical strategies. Nat Rev Cancer 3, 330–338 (2003). https://doi.org/10.1038/nrc1074 2. Chen D, Jansson A, Sim D, Larsson A, Nordlund P. Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states. J Biol Chem. 2017 Aug 11;292(32):13449-13458. doi: 10.1074/jbc.M117.787267. Epub 2017 Jun 20. PMID: 28634233; PMCID: PMC5555203. 3. Jagdish Chander, Harmanjit Singh, Dinesh Joshi, 7.24 - 5-Flucytosine, Editor(s): Terry Kenakin, Comprehensive Pharmacology, Elsevier, 2022, Pages 384-392, ISBN 9780128208762, https://doi.org/10.1016/B978-0-12-820.... (https://www.sciencedirect.com/science...)