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The 8th World Congress of Laparoscopic Surgeons (WALS) 2025, held at The Leela Ambience Gurugram, brought together leading experts in minimal access surgery to discuss the latest advancements and innovations. Among the key highlights of the conference was a groundbreaking talk by Dr. Steven D. Wexner, a globally renowned colorectal surgeon, on the Consensus Statement for Fluorescence-Guided Surgery (FGS). His session emphasized the transformative impact of fluorescence imaging in enhancing surgical precision, improving patient outcomes, and standardizing the use of this technology across various surgical specialties. The Role of Fluorescence-Guided Surgery in Modern Medicine Fluorescence-guided surgery (FGS) has emerged as a powerful tool in minimally invasive and robotic-assisted procedures, allowing real-time visualization of critical anatomical structures. The technique employs fluorophores such as indocyanine green (ICG) to enhance tissue differentiation, improve lymphatic mapping, and assess tissue perfusion. Dr. Wexner highlighted key clinical applications of FGS, including: • Colorectal Surgery: Enhancing anastomotic perfusion to reduce the risk of leaks. • Hepatobiliary and Pancreatic Surgery: Improving tumor margin visualization. • Gynecological Oncology: Assisting in sentinel lymph node mapping. • Thoracic Surgery: Aiding in segmental lung resection and metastasis localization. Key Points from the Consensus Statement on Fluorescence-Guided Surgery During his talk, Dr. Wexner outlined the global consensus guidelines developed by leading surgical societies to optimize the implementation of FGS. The consensus focused on the following aspects: 1. Standardization of FGS Protocols • Establishing clear dosing regimens for ICG and other fluorophores. • Defining standardized fluorescence thresholds for decision-making. 2. Clinical Applications and Efficacy • Multi-center trials have demonstrated a significant reduction in anastomotic leak rates in colorectal surgery when FGS is used. • The early detection of ischemic bowel segments has improved post-surgical outcomes. 3. Technological Advancements • Integration of near-infrared (NIR) fluorescence imaging with robotic platforms for enhanced real-time guidance. • Development of multi-wavelength fluorescence imaging systems for superior tissue differentiation. 4. Surgeon Training and Skill Development • Incorporating fluorescence imaging modules into surgical training curricula. • Promoting global collaboration to improve the adoption of FGS across healthcare systems. Future Directions and Global Adoption Dr. Wexner emphasized the need for further research and standardization to ensure the widespread adoption of fluorescence-guided techniques. Future advancements in molecular imaging agents and AI-assisted fluorescence interpretation are expected to further refine surgical precision. To maximize the benefits of FGS, multidisciplinary collaboration between surgeons, radiologists, and biomedical engineers is essential. The consensus statement serves as a roadmap for integrating fluorescence imaging into routine surgical practice, ensuring that patient safety and surgical accuracy remain top priorities. Conclusion Dr. Steven D. Wexner’s presentation at WALS 2025 provided a pivotal update on fluorescence-guided surgery, reinforcing its clinical benefits and future potential. With the adoption of standardized guidelines, FGS is poised to become a mainstay in modern surgery, offering greater precision, improved patient safety, and enhanced outcomes across multiple disciplines. As technology continues to evolve, fluorescence-guided techniques will play an integral role in the next era of minimally invasive and robotic surgery.