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CHAPTERS: 0:00 - Welcome and Introduction, Bert Kasiske 2:01 - Living with CADASIL, Ki Coale 28:36 - The Year in Review, Nikolaos Karvelas 45:03 - What can the heterogeneity of CADASIL tell us about prediction of clinical course impact on treatments, now and in the future?, Bert Kasiske 47:55 - Genotype-based risk stratification in NOTCH3-associated small vessel disease, including CADASIL, Julie Rutten 1:09:07 - CADASIL Heterogeneity: How it affects development of therapies, Micheal Wang 1:26:42 - Ongoing CADASIL studies in the US, Jane Gunther 1:28:07 - The CADASIL Consortium, Karen Orjuela 1:36:20 - NIH/NHLBI Study, Elisa Ferrante 1:49:13 - CZI Patient-Partnered Collaboration for Rare Neurodegenerative Disease, Fanny Elahi 1:59:35 - CADASIL Community Natural History Study, Bert Kasiske 2:07:45 - Clinical trials past, present and future, Jane Gunther & Fanny Elahi 2:31:12 - Panel of patients & investigators ULF ANNUAL FAMILY CONFERENCE 2025: cureCADASIL Patient-Investigator Meeting Want to learn more? Learn about CADASIL, how to participate in clinical trials, and how to donate to promote CADASIL research at cureCADASIL.org. Disclaimer: The views and opinions expressed in this video are those of the individual(s) featured and do not necessarily reflect the official stance or views of the ULF. The ULF or cureCADASIL is not responsible for any content, statements, or claims made in this video.