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#258

Autoimmunity to urothelial antigen causes bladder inflammation, pelvic pain and voiding dysfunction: a novel animal model for Hunner type interstitial cystitis Akiyama Y1, Lutgendorf S1, Kreder K1, O’Donnell M1, Homma Y2, Kume H2, Luo Y1 1. Department of Urology, University of Iowa, 2. Department of Urology, The University of Tokyo KEYWORDS: Animal Study, Basic Science, Painful Bladder Syndrome/Interstitial Cystitis (IC) Hunner type interstitial cystitis (HIC) is a chronic inflammatory disorder of the urinary bladder characterized by persistent pelvic/bladder pain, urinary frequency and/or urgency. Histologically, HIC bladder manifests subepithelial chronic inflammatory changes such as lymphoplasmacytic infiltration, epithelial denudation, and stromal oedema, neovascularization and hyperemia. To date, few animal models which reproduce the histological and clinical correlates of HIC have been yet established. Although the aetiology of HIC remains elude, recent evidence suggests that enhanced immune responses may underlie the pathophysiology of HIC (1). The higher prevalence of comorbid systemic autoimmune disorders is a well-known fact in patients with HIC. Based on this evidence, we aimed to develop a novel animal model for HIC via autoimmunity to the bladder urothelium in this study. Read the full abstract text here: https://www.ics.org/2020/abstract/258