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Watch the full video at https://www.jove.com/v/12180?utm_sour... Explore our full cell biology video textbook at https://www.jove.com/science-educatio... JoVE is the world-leading producer and provider of science videos with a mission to accelerate scientific research and education. Millions of scientists, educators and students across 1500+ High Schools, colleges and universities worldwide use JoVE’s library of 17,000+ videos for teaching, learning and research. JoVE High Schools offers expert-created video textbooks, lab videos, science experiment videos, interactive assessments, and seamless integration into school systems. These comprehensive learning resources help educators tackle teaching challenges, engage students, and meet curriculum requirements, enhancing the high school learning experience. Subscribe to our YouTube Channel - / @jovehighschools Follow us on - Facebook - / jovehighschools Instagram - / jovehighschools The patch-clamp technique is an electrophysiological tool to study the ion channel behavior of excitable cells like neurons and muscle fibers. The patch-clamp setup includes a glass micropipette placed against a small area of cell membrane containing one or more ion channels. It consists of an electrolyte solution and a chlorinated silver electrode to measure voltages and currents.