Immunology: B cell maturation скачать в хорошем качестве

Immunology: B cell maturation

B cells undergo two types of selection while developing in the bone marrow to ensure proper development. Positive selection occurs through antigen-independent signaling involving both the pre-BCR and the BCR.[5][6] If these receptors do not bind to their ligand, B cells do not receive the proper signals and cease to develop.[5][6] Negative selection occurs through the binding of self-antigen with the BCR; If the BCR can bind strongly to self-antigen, then the B cell undergoes one of four fates: clonal deletion, receptor editing, anergy, or ignorance (B cell ignores signal and continues development).[6] This negative selection process leads to a state of central tolerance, in which the mature B cells don't bind with self antigens present in the bone marrow.[4] To complete development into mature b cells, immature B cells migrate from the bone marrow to the spleen as well as pass through two transitional stages: T1 and T2.[7] Throughout their migration to the spleen and after spleen entry, they are considered T1 B cells.[8] Within the spleen, T1 B cells transition to T2 B cells.[8] T2 B cells differentiate into either follicular (FO) B cells or marginal zone (MZ) B cells depending on signals received through the BCR and other receptors.[9] Once differentiated, they are now considered mature B cells, or naive B cells.[8] The 1976 copyright act entitles fair use for non profit educational purposes and is extended under the DMCA, see title 17 section 107 of the us copyright code. my videos aren't monetized I do this for myself