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Las #alergias son una reacción del sistema inmunitario en respuesta a los #alergenos alimentarios o ambientales, en ocasiones es por una predisposición genética y es el resultado desafortunado de la evolución de la respuesta inmunitaria con IgE en contra de #parasitos metazoarios. Conoce aquí lo que está detrás de esta respuesta inmunitaria. ______________________________________________ Artículos consultados: Akdis, C. A., Akdis, M., Boyd, S. D., Sampath, V., Galli, S. J., & Nadeau, K. C. (2023). Allergy: Mechanistic insights into new methods of prevention and therapy. Science translational medicine, 15(679), eadd2563. https://doi.org/10.1126/scitranslmed.... Vander Does, A., Labib, A., & Yosipovitch, G. (2022). Update on mosquito bite reaction: Itch and hypersensitivity, pathophysiology, prevention, and treatment. Frontiers in immunology, 13, 1024559. https://doi.org/10.3389/fimmu.2022.10... Campbell, E., Hesser, L. A., & Nagler, C. R. (2021). B cells and the microbiota: a missing connection in food allergy. Mucosal immunology, 14(1), 4–13. https://doi.org/10.1038/s41385-020-00... Pacheco, S. E., Guidos-Fogelbach, G., Annesi-Maesano, I., Pawankar, R., D' Amato, G., Latour-Staffeld, P., Urrutia-Pereira, M., Kesic, M. J., Hernandez, M. L., & American Academy of Allergy, Asthma & Immunology Environmental Exposures and Respiratory Health Committee (2021). Climate change and global issues in allergy and immunology. The Journal of allergy and clinical immunology, 148(6), 1366–1377. https://doi.org/10.1016/j.jaci.2021.1... Pierau, M., Arra, A., & Brunner-Weinzierl, M. C. (2021). Preventing Atopic Diseases During Childhood - Early Exposure Matters. Frontiers in immunology, 12, 617731. https://doi.org/10.3389/fimmu.2021.61... Alkotob, S. S., Cannedy, C., Harter, K., Movassagh, H., Paudel, B., Prunicki, M., Sampath, V., Schikowski, T., Smith, E., Zhao, Q., Traidl-Hoffmann, C., & Nadeau, K. C. (2020). Advances and novel developments in environmental influences on the development of atopic diseases. Allergy, 75(12), 3077–3086. https://doi.org/10.1111/all.14624 McSorley, H. J., Chayé, M. A. M., & Smits, H. H. (2019). Worms: Pernicious parasites or allies against allergies?. Parasite immunology, 41(6), e12574. https://doi.org/10.1111/pim.12574 Fitzsimmons, C. M., Falcone, F. H., & Dunne, D. W. (2014). Helminth Allergens, Parasite-Specific IgE, and Its Protective Role in Human Immunity. Frontiers in immunology, 5, 61. https://doi.org/10.3389/fimmu.2014.00061 Prokopakis, E., Vardouniotis, A., Kawauchi, H., Scadding, G., Georgalas, C., Hellings, P., Velegrakis, G., & Kalogjera, L. (2013). The pathophysiology of the hygiene hypothesis. International journal of pediatric otorhinolaryngology, 77(7), 1065–1071. https://doi.org/10.1016/j.ijporl.2013... Fitzsimmons, C. M., & Dunne, D. W. (2009). Survival of the fittest: allergology or parasitology?. Trends in parasitology, 25(10), 447–451. https://doi.org/10.1016/j.pt.2009.07.004 Fallon, P. G., & Mangan, N. E. (2007). Suppression of TH2-type allergic reactions by helminth infection. Nature reviews. Immunology, 7(3), 220–230. https://doi.org/10.1038/nri2039 Kim, Y. K., Cho, S. H., Koh, Y. Y., Son, J. W., Lee, B. J., Min, K. U., & Kim, Y. Y. (1999). Linkage between IgE receptor-mediated histamine releasability from basophils and gene marker of chromosome 11q13. The Journal of allergy and clinical immunology, 104(3 Pt 1), 618–622. https://doi.org/10.1016/s0091-6749(99... ______________________________________________ Libros recomendados: Male, D, Stokes Peebles, R, Male, V. (2021). Inmunología. Elsevier. Thao, D, Richard A. Harvey, RA. (2021). LIR Inmunología. LWW Wolters Kluwer. Abbas, AK, Lichtman, AH, Pillai, S. (2020). Inmunología Básica. Elsevier. Punt, J, Strandford, SA, Jones PP, Owen JA. (2020). Kuby. Inmunología. McGrawHill. Sompayrac, LM. (2019). How the Immune System Works. Wiley-Blackwell Tizard, I. (2019). Inmunología Veterinaria. Elsevier. ______________________________________________ Imagen de fibras musculares: https://commons.wikimedia.org/wiki/Fi.... Berkshire Community College Bioscience, CC0, via Wikimedia Commons Imágenes (varias): https://www.svgrepo.com/. SVF Repo - Free SVG Vectors and Icons.