Diuretics | Pharmacology | Dr Najeeb скачать в хорошем качестве

Diuretics | Pharmacology | Dr Najeeb

#drnajeeb #medicines #pharmacology #diuretics Diuretics | Pharmacology | Dr Najeeb Like this video? Sign up now on our website at https://www.DrNajeebLectures.com to access 1000+ Exclusive videos on Basic Medical Sciences & Clinical Medicine. These are premium videos (NOT FROM YOUTUBE). All these videos come with English subtitles & download options. Sign up now! Get Lifetime Access for a one-time payment of $99 ONLY! Sign up now on our website at https://members.drnajeeblectures.com/... --------------------------------------------------------------------------------------------------------------------------- Why sign up for premium membership? Here's why! Membership Features for premium website members. 1. More than 1000+ Medical Lectures. 2. Basic Medical Sciences & Clinical Medicine. 3. Mobile-friendly interface with android and iOS apps. 4. English subtitles and new videos every week. 5. Download option for offline video playback. 6. Fanatic customer support and that's 24/7. 7. Fast video playback option to learn faster. 8. Trusted by over 2M+ students in 190 countries. --------------------------------------------------------------------------------------------------------------------------- Diuretics-Pharmacology 00:00:00 Diuretic and Natriuretic. 00:02:02 Relationship between Cardiac Output (CO) and Renal Blood Flow (RBF), Percentage of RBF ending up as Filtrate; Concept of Glomerular Filtration Rate (GFR) as a function of CO and RBF. Understanding the role of processes such as Filtration, Reabsorption and Secretion. 00:16:19 Percentage ending up as Final Urine Volume, Clinical co-relate: Oliguria, Polyuria; Nephron as the "Master Processor". 00:28:59 Diuretic and Natriuretic drugs' action on nephrons. 00:30:26 Outline: Mechanisms and sites of Reabsorption (Na+ primarily), 1-Proximal Convoluted Tubule (PCT) 2-Thick part of Ascending Loop of Henle (TALOH) 3-Distal Convoluted Tubule (DCT) 4-Collecting Tubule (CT) 00:33:42 1-Proximal Convoluted Tubule (PCT); Anatomy of PCT & mechanisms of Reabsorption, Secretion, Exchange (Na+, H+, HCO3-), Role of Na+H+-counter transporter and Na+K+ ATPases. 00:50:00 Carbonic Anhydrase (CA) enzyme, H2CO3 (Carbonic Acid); [HCO3- and H+] and the drugs that act through blocking CA enzyme (CA inhibitors); Increased Na+, HCO3- and H2O in urine: Acetazolamide. 01:00:29 4-Collecting Tubule (CT) : Principal cells, Mechanisms of K+ wasting (Kaliuretic); K+ Wasters = All Diuretics acting proximal to CT. 01:13:00 Descending LOH: Freely permeable to H2O [along with PCT]; Ascending parts of LOH + initial DCT fully impermeable to H2O, Role of ADH in CT's water permeability and excretion of dilute and concentrated urine, Osmolarities in various parts of tubule & its rationale. 01:35:56 2-Thick part of Ascending Limb of Loop of Henle (TALOH); Na+ K+ 2Cl- Co-transporter, K+ leaky channels on luminal side; electro positivity in lumen and its effect on Ca+, Mg+ reabsorption; Drugs blocking NaKCl co-transporter; Loop Diuretics [Furosemide etc.]; Kaliuretic + Calcinuria + Magnesiumurea 02:04:15 3-Distal Convoluted Tubule (DCT): Na+Cl- co-transporter, Na+Ca+ counter transporter, role of Parathyroid hormone (PTH), Thiazide Diuretics as Ca+ retaining drugs; Renal stones. 02:19:15 Comparing Thiazide Diuretics, Furosemide and their effect on Ca+ absorption & its clinical implications; Osteoporosis, Hyperuricemia. Interaction with NSAIDS. 02:26:35 Drugs acting distally to DCT; Antikaliuretic drugs: Importance of Principal cells in K+ balance, Na+ channel blocking drugs, Role of Aldosterone; 02:48:50 Effects of Diuretics on Principal Cells; Amiloride, Triamterene; K+ Sparing drugs. Aldosterone Receptor Blockers (ARBs): Spironolactone 02:54:54 Osmotic Diuresis; PCT: Mannitol; Increased Extracellular Fluid Volume (ECFV) --------------------------------------------------------------------------------------------------------------------------- Join this channel to get access to perks: Sign up now on our website at https://members.drnajeeblectures.com/...    / @doctornajeeb   Follow us on Facebook :-   / drnajeeb   Follow us on Instagram :-   / drnajeeblectures