Drs. Sean Gibbons & Christian Diener on the gut microbiome’s supersized role in shaping metabolites скачать в хорошем качестве

Drs. Sean Gibbons & Christian Diener on the gut microbiome’s supersized role in shaping metabolites

Scientists from the Institute for Systems Biology in Seattle have shown which blood metabolites are associated with the gut microbiome, genetics, or the interplay between both. Their findings, published in the journal Nature Metabolism, have promising implications for guiding targeted therapies designed to alter the composition of the blood metabolome to improve human health. In this video, lead author Dr. Christian Diener and co-corresponding author Dr. Sean Gibbons discuss their findings with ISB President Dr. Jim Heath. 0:00 Dr. Jim Heath introduces Drs. Gibbons and Diener 0:24 Dr. Heath: Nature Metabolism paper by Drs. Gibbons, Diener and colleagues 0:40 Dr. Heath: Measuring "omics" – genome, transcriptome, proteome, metabolome, and what it means 01:24 Dr. Diener: Most metabolites in our blood are driven by the gut microbiome 02:07 Dr. Gibbons: In some cases, genome and microbiome explain variability in metabolite, but independent of one another 03:23 Dr. Gibbons: Goal is to provide community resource that can help shape therapeutics