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Stuart Firestein, PhD, joins Nick Dirks in the fourth episode of Shaping Science to discuss the science of smells, learning from failure, and the utility of uncertainty. Formerly the Chair of the Department of Biological Sciences at Columbia University, Prof. Firestein is the author of “Ignorance: How it Drives Science” and “Failure: Why Science is So Successful,” which have been translated into 12 languages. Shaping Science is made possible with the generous support of Tata Sons. For more info, visit: nyas.org/ideas-insights/podcasts/ Also watch Prof. Firestein's TED Talks: • Ignorance -- the critical driver for scien... • Stuart Firestein: The pursuit of ignorance • How failure can be a path into the unimagi... 00:00 Intro 01:59 How Memorizing Theatre Lines Led to Success in Organic Chemistry 10:04 Debating the Sensory Dominance of Smell for Dogs 15:01 The Most Interesting Components of Smell for Humans 18:50 Neuroscience and Artificial Intelligence 20:49 Controlling for the Aging Brain 26:56 Ignorance and Knowing What You Don't Know 32:49 Handling Failure and Uncovering the Unknown Unknowns 36:08 Finding the Balance Between Failure and Success 39:39 Assessing the Current State of Funding for Science