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“Problems with high dose T3 therapy part two” One important thing to understand is that if you are on T3 and you feel great. My problem with T3 therapy is that I don’t think we are addressing the underlying issue. The real issue is why are the cells not wanting to convert T4 to T3, we are just providing what we see on a lab test. Why would T3 be low if you have a functioning thyroid gland or if you are on T4? 1-T3 could be low because there is a decrease in T4 conversion to T3. This is usually not the case early on, but it is a possibility. 2- T3 could be low because there is a cell stress response going on so the tissues don’t want to convert T4 to T3. This is what I usually see with my patients. Is there a downside to loading a person with T3 medication? Yes. And here's what can happen. 1- An increase in sex hormone binding globulin. This decreases free hormones. 2- An increase in ferritin. This increases inflammation and oxidative stress. 3- Doesn’t address the root issue. Adding T3 medication makes the labs look better and might temporarily help your symptoms, but oftentimes people end up on stronger, and stronger doses and still don’t feel well. Have any questions about T3? Leave them below!