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In this ESMO-SIOG video, Nicolò Battisti underlines the importance of performing Comprehensive Geriatric Assessment (CGA), as patients over 65 years old represent half of the cancer patients population. He explains why a personalised and multidisciplinary approach is necessary in the management of this very heterogeneous population and details CGA tools. He discusses results from 4 geriatric oncology landmark studies presented at ASCO 2020 Annual Meeting in terms of positive impact of CGA intervention on study endpoints. Abstracts from ASCO 2020 Annual Meeting: 12009: A geriatric assessment (GA) intervention to reduce treatment toxicity in older patients with advanced cancer: A University of Rochester Cancer Center NCI community oncology research program cluster randomized clinical trial (CRCT), by Supriya Gupta Mohile 12010: Geriatric assessment-driven intervention (GAIN) on chemotherapy toxicity in older adults with cancer: A randomized controlled trial, by Daneng Li 12011: Integrated geriatric assessment and treatment (INTEGERATE) in older people with cancer planned for systemic anticancer therapy, by Wee-Kheng Soo 12012: Randomized trial of a perioperative geriatric intervention for older adults with cancer, by Ryan Nipp Produced by ESMO, https://oncologypro.esmo.org