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This talk is part of the INOVAIT Lecture Series and was presented on April 8, 2021. In this lecture Nissan Elimelech, Founder and CEO of Augmedics, provides an overview of the current state of artificial intelligence (AI) in image-guided therapy with a special focus on combining AI and augmented reality (AR) to advance image-guided surgery. Nissan discusses key points in starting a company and commercializing a technology in the AR and surgical navigation space, drawing reference to his experience in founding Augmedics, a company that is currently developing the first AR navigation technology to be used in surgery, allowing surgeons to see the patient’s anatomy through skin and tissues. Topics include the role of AI in image-guided surgery and surgical navigation, current and potential AR applications and technological developments in image-guided surgery, and potential commercialization gaps, challenges and rewards. Visit us at inovait.ca.