New approach methods for adult and developmental neurotoxicity скачать в хорошем качестве

New approach methods for adult and developmental neurotoxicity

This ECHA science seminar features Prof. Dr. Ellen Fritsche (Swiss Centre for Applied Human Toxicology, Basel), Dr. Jonathan Blum (Swiss Centre for Applied Human Toxicology, Basel), and Prof. Dr. Tamara Tal (Helmholtz Centre for Environmental Research) exploring the potential and challenges of applying new approach methods (NAMs) to distinguish and assess adult neurotoxicity (ANT) and developmental neurotoxicity (DNT), and how this evidence could inform future CLP classification. The video begins by clarifying ANT vs. DNT and why timing, life-stage, and cell type are critical. The speakers introduce the DNT in vitro battery (DNT IVB), discuss AOP networks that integrate developmental context, and outline how a unified, expanded neurotoxicity battery could improve decision‑making while reducing animal testing. Key regulatory challenges: ▪ How can NAMs differentiate between ANT and DNT? ▪ How could ANT/DNT NAMs potentially fit in the current CLP hazard classes? ▪ How could ANT/DNT NAMs potentially support any future CLP paradigm for neurotoxicity? The seminar will also present the different assays developed under PARC. Case studies (e.g. ethanol, retinoic acid, organophosphates, PFAS) illustrate how mechanisms can overlap across life‑stages while potency and outcomes differ, and how AOP‑anchored testing guides interpretation. This video is essential viewing for professionals in chemical regulation, risk assessment, research and development and neurotoxicology interested in advancing regulatory‑relevant NAMs for human health protection. Our science seminars cover a wide range of topics related to chemical safety, regulatory science, and innovative research in the field of chemicals management, focussing on human health and the environment. They aim to establish the regulatory relevance and uptake of research for ECHA’s scientific work. More: https://echa.europa.eu/science ************** Subscribe to our channel: https://bit.ly/321VQgE Subscribe to our Safer Chemicals Podcast: https://echa.europa.eu/podcasts Subscribe to our news: https://echa.europa.eu/subscribe Follow us on: *LinkedIn:   / european-chemicals-agency   *X: https://x.com/EU_ECHA *BlueSky: https://bsky.app/profile/echa.europa.eu *Facebook:   / euecha   *Instagram:   / onehealth_eu   Visit our website: https://echa.europa.eu/ Disclaimer: Views expressed by presenters do not necessarily represent the official position of the European Chemicals Agency. All content is up to date at the time of publication.