Introduction to Pharmacokinetics: ADME Overview | Pharmacology скачать в хорошем качестве

Introduction to Pharmacokinetics: ADME Overview | Pharmacology

Watch next - Drug absorption:    • Drug Absorption - Pharmacokinetics | ...   If you'd like to support EKG Science 💙 PayPal - https://www.paypal.com/paypalme/ekgsc... --- In this lecture EKG is going to cover an introduction to pharmacokinetics, looking at an overview of the four main processes, which are absorption, distribution, metabolism, and excretion. We’ll also break down some key pharmacokinetic concepts, such as bioavailability, first-pass metabolism, and half-life, describe their clinical importance, and start seeing how we can calculate such parameters. And then, in later pharmacokinetics lectures, we’re going to expand on these topics. Table of Contents: 0:00 Intro 0:35 Pharmacodynamics vs Pharmacokinetics 2:03 Drug Absorption: Routes Of Administration, Factors Influencing Absorption & Mechanism 9:41 Bioavailability (F) 12:07 Oral vs Intravenous Administration 16:30 Drug Distribution: Factors Influencing Distribution & Specific Barriers 19:55 Drug Apparent Volumed Of Distribution (Vd) 22:00 Drug Elimination Overview 22:17 Drug Metabolism: Phase I & Phase II Reactions 29:30 Drug Excretion 30:50 Drug Dosage & Blood Levels 34:30 Half-Life & Clearance: Zero & First Order Kinetics 39:56 Pharmacokinetics Variability For educational purposes only; NOT medical or other advice. Lecture Source: Ritter, J., Flower, R.J., Henderson, G., Yoon Kong Loke and Rang, H.P. (2018). Rang and Dale’s Pharmacology. 9th ed. Endinburgh: Elsevier. #pharmacokinetics #pharmacology #ekgscience