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In patients over 70, amyloid angiopathy can be a cause of intracranial hemorrhage. This condition is caused by pathologic accumulation of amyloid in vessel walls, and is characterized by multiple chronic areas of hemorrhage in a peripheral location. Other cerebral manifestations of amyloid also occur, including: amyloidoma - a tumorlike mass with surrounding edema inflammatory amyloid - an inflammatory condition similar to an acute encephalopathy. There is sometimes overlap between these conditions. Amyloid is associated with Down syndrome as well as Alzheimer disease, which should make you more on the lookout for this condition. The level of this lecture is appropriate for medical students, junior residents, and trainees in other specialties who have an interest in neuroradiology or may see patients with intracranial hemorrhage or stroke. Check out this video and additional content on http://www.learnneuroradiology.com