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In this "Ask Me Anything" (AMA) episode, Peter explores the complex world of supplements by introducing a practical framework for evaluating their effectiveness and relevance to individual health needs. Rather than providing a simple list of recommendations, Peter aims to equip listeners with the tools to critically assess supplements on their own. He then applies this framework to discuss research on several popular supplements, including creatine, fish oil, vitamin D, B vitamins, and ashwagandha. Additionally, he covers key factors in assessing supplement quality, helping listeners develop a deeper understanding of how to make informed decisions based on their personal health goals. View show notes here: https://bit.ly/428dGiB Become a member to receive exclusive content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ We discuss: 00:00 - Intro 01:36 - Overview of episode topics 03:12 - How Peter evaluates patients’ supplement regimens, and common misconceptions about supplements vs. pharmaceuticals 07:12 - A framework for evaluating supplements 11:17 - Evaluating creatine: purpose of supplementation, dosing, and mechanism of action 14:19 - Creatine: proven benefits for muscle performance, potential cognitive benefits, and why women may benefit more 21:42 - Creatine: risk vs. reward, kidney concerns, and choosing the right supplement 23:56 - Evaluating fish oil: its primary purpose as a supplement and how to track levels In the full episode, we also discuss: -Fish oil: how omega-3s impact inflammation, heart health, and brain function, and the strengths and limitations of current research -Fish oil: the risks of supplementation, guidance on selecting high-quality products, and how to determine whether supplementation is appropriate -Evaluating vitamin D: understanding deficiency and optimal levels -Vitamin D: role in bone health, immune function, potential longevity impact, and biomarker limitations -Vitamin D: efficacy, safety, and balancing risk vs. reward -Evaluating B vitamins: function, consequences of deficiency, and key biomarkers to assess whether supplementation is necessary -B vitamins: risks for CVD and dementia associated with deficiency, and limited evidence for general population supplementation -Evaluating ashwagandha: background, uses, and mechanism of action -Ashwagandha: current evidence for its effects on sleep, stress, and anxiety -Ashwagandha: evaluating supplement quality, safety profile, and the risk-reward balance -The importance of using a structured evaluation framework to assess any supplement -More. -------- About: The Peter Attia Drive is a deep-dive podcast focusing on maximizing longevity, and all that goes into that from physical to cognitive to emotional health. With over 90 million episodes downloaded, it features topics including exercise, nutritional biochemistry, cardiovascular disease, Alzheimer’s disease, cancer, mental health, and much more. Peter Attia is the founder of Early Medical, a medical practice that applies the principles of Medicine 3.0 to patients with the goal of lengthening their lifespan and simultaneously improving their healthspan. Learn more: https://peterattiamd.com Connect with Peter on: Facebook: http://bit.ly/PeterAttiaMDFB Twitter: http://bit.ly/PeterAttiaMDTW Instagram: http://bit.ly/PeterAttiaMDIG Subscribe to The Drive: Apple Podcast: http://bit.ly/TheDriveApplePodcasts Overcast: http://bit.ly/TheDriveOvercast Spotify: http://bit.ly/TheDriveSpotify Google Podcasts: http://bit.ly/TheDriveGoogle Disclaimer: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions. I take conflicts of interest very seriously. For all of my disclosures and the companies I invest in or advise, please visit my website where I keep an up-to-date and active list of such companies. For a full list of our registered and unregistered trademarks, trade names, and service marks, please review our Terms of Use: https://peterattiamd.com/terms-of-use/