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Trust for America’s Health (TFAH) hosted a national webinar on our recently released report, Pain in the Nation 2024: The Epidemics of Alcohol, Drug, and Suicide Deaths. TFAH’s report found that a decrease in the alcohol-induced mortality rate led to a slightly lower combined rate of all U.S. deaths due to alcohol, drugs, and suicide in 2022, but the long-term trend of such deaths is still alarmingly high. Between 2002 and 2022, combined deaths due to alcohol, drugs, and suicide have increased by 142 percent from 74,003 deaths in 2002 to 207,827 deaths in 2022. For 2022, the alcohol-induced mortality rate decreased by six percent to 13.5 deaths per 100,000 people, the first decrease in the rate after more than a decade of increases, but death rates for drug overdose and suicide remained unchanged. The report also includes a special feature on polysubstance misuse and overdose. We discussed steps policymakers should take to begin to reverse these crises.