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📢 Ask Dr. Bikman’s Digital Mind (multilingual): https://benbikman.com/ben-bikmans-dig... 📢 Dr. Bikman’s Community & Coaching Site, Insulin IQ: https://insuliniq.com 📢 Become an Insider, Ben’s website: https://www.benbikman.com In this lecture, Dr. Bikman explores how ketogenesis—our body's ability to produce ketones from fat—operates differently in men and women. While the foundational metabolic machinery is the same, hormonal influences, fat distribution, and physiological demands like pregnancy and lactation create meaningful divergences in how each sex mobilizes fat and enters ketosis. Women typically exhibit higher levels of free fatty acids and ketones during fasting compared to men. Estrogen drives this effect by enhancing both fat storage in subcutaneous areas and the enzymes responsible for fat breakdown. This dual effect—storing fat in a metabolically healthy way and releasing it efficiently when needed—makes women more metabolically flexible, especially during periods of energy demand like fasting or exercise. Men, by contrast, tend to have higher lean mass and rely more heavily on glucose oxidation. Their metabolic machinery still supports fat burning and ketogenesis but often ramps up more slowly. Interestingly, while women tend to reach ketosis faster, men may show more consistent weight loss over time on ketogenic diets—partly due to greater muscle mass and a more sustained shift toward fat burning once adapted. A fascinating part of the lecture touches on lactation-induced ketoacidosis, a rare but documented condition in breastfeeding women following strict low-carb diets. This underscores how a woman’s enhanced capacity for fat mobilization and ketone production, while advantageous, can potentially overshoot during intense metabolic demands—highlighting the importance of mindful dietary strategies that are tailored to sex-specific physiology. Show Notes/References: For complete show notes and references, we invite you to become an Insider subscriber or member. You’ll enjoy real-time, livestream Metabolic Classroom access which includes live Q&A with Ben after the lecture, unlimited access to Dr. Bikman’s Digital Mind, ad-free podcast episodes, show notes and references, and online, live Office Hours access with Ben. It also includes Ben’s Weekly Research Review Podcast, and a searchable archive. Learn more: https://www.benbikman.com Translation Notes: You can click the gear icon at the bottom of this video to auto-translate captions. For example, to translate into Polish, select Subtitles, choose Auto-Translate, then first choose English, then choose Auto-Translate again, then choose Polish.) Also, Dr. Bikman’s Digital Mind can interact with you in many languages: https://benbikman.com/ben-bikmans-dig... In addition, our channel has access to YouTube’s innovative “auto-dubbing” feature. The process supports translations from English into many languages, with more to come. Click on the gear icon, then choose “Audio track” to access. (This availability is often delayed several weeks or more, so check back often.) Timestamps (approximate): 03:12 – Fat Cells: Energy Storage and Release 04:25 – Free Fatty Acids and Liver Ketogenesis 05:47 – Ketone Formation via Beta-Oxidation 06:49 – Ketones as Fuel for the Whole Body 07:55 – Women Have Higher Free Fatty Acids 09:00 – Fat Distribution: Subcutaneous vs. Visceral 10:05 – Estrogen’s Role in Fat Turnover 13:32 – Women Enter Ketosis Faster 14:36 – Human Tracer Studies Confirm Partitioning Differences 17:20 – Animal vs. Human Responses to Ketogenic Diets 18:30 – Study: Women Store More Fat on Keto in Mice 19:40 – Why Human Data Are Harder to Interpret 21:00 – Summary: Ketosis Differences by Sex 22:15 – Evolutionary Perspective on Female Adaptability 23:30 – Lactation, Lipolysis, and Ketone Enrichment in Milk 27:25 – Practical Implications: Tailoring Keto by Sex IMPORTANT NOTE: The information presented is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Dr. Bikman is not a clinician—and, he is not your doctor. Always seek the advice of your own qualified health providers with questions you may have regarding medical conditions. #ketones #ketogenesis #metabolichealth #womenshealth #fasting #keto #DrBenBikman #hormones #fatburning #insulinresistance #estrogen #lipolysis #ketodiet #metabolicflexibility #menvswomen #subcutaneousfat #lactation #fatloss #nutritiondifferences #metabolicclassroom Ben’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/1BA884 Exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code BEN10 for a 10% discount: https://cleanformnutrition.com/produc... Ben’s favorite meal-replacement shake: https://gethlth.com (discount: BEN10) Ben’s favorite allulose source: https://rxsugar.com (discount: BEN20) Ben’s favorite health check-up for men: https://blokes.co/drben15 (discount: DRBEN15)