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I. Psychedelics and Emotional Processing Serotonergic psychedelics are explored for psychiatric conditions. Their effects on emotional processing may drive clinical efficacy. However, studies show complex effects on human emotions and mood. Psychedelics may promote emotional flexibility and adaptation. They effectively modulate emotion regulation strategies. II. Neuroplasticity and Mood Disorders Chronic mood disorders feature synaptic plasticity dysfunction. Plasticity is the brain's ability to reorganize connections. Decreased plasticity associated gene transcription is seen. This includes brain-derived neurotrophic factor, or BDNF. Such dysfunction disrupts learning and cognitive flexibility. III. Emotion Regulation Brain Circuits Mood regulation involves specific complex brain circuits. The amygdalar-hippocampal-prefrontal circuit is very key. This particular circuit is implicated in mood disorders. These brain circuits are highly amenable to neural plasticity. Restoring plasticity here reduces severe disorder symptoms. IV. The Psychoplastogen Hypothesis Psychedelics may act as psychoplastogens to boost plasticity. They induce neuronal growth and enhance synaptic connections. Compounds like psilocybin and LSD enhance synaptogenesis. They promote growth in the prefrontal cortex and hippocampus. A single dose of LSD produces increases in human BDNF levels. Neural plasticity plays a central role in emotion regulation. V. Additional Resource Support See NourishED RFI's NotebookLM Resource Support Page. https://notebooklm.google.com/noteboo... VI. Source Source: Moujaes, F., Rieser, N. M., Belinger, L., Herdener, M., Zahid, Z., & Preller, K. H. (2025). The emotional architecture of the psychedelic brain. Trends in Cognitive Sciences, 29(11), 1007-1018. https://doi.org/10.1016/j.tics.2025.0... Disclaimer: This is AI-generated content reviewed by a PhD researcher with a PhD in Biomedical Science & neuroscience (Brenna Bray, PhD). #psychedelicscience #psychedelicresearch #Neuroplasticity #emotionalprocessing #MentalHealth #Neuroscience #BrainCircuits #amygdala #prefrontalcortex #bdnf