Difference Between Physostigmine and Neostigmine | GPAT | NIPER | Pharmacist | Drugs Inspector скачать в хорошем качестве

Difference Between Physostigmine and Neostigmine | GPAT | NIPER | Pharmacist | Drugs Inspector

Download the "Solution Pharmacy" Mobile App to Get All Uploaded Notes, Model Question Papers, Answer Papers, Online Tests and other GPAT Materials - https://play.google.com/store/apps/de... Book Review Video -    • Text Book of Pharmacology By Prasan R  Bha...   Purchase from Amazon = https://amzn.to/3S0K68h Table of Content https://www.thieme.in/image/catalog/T... Sample Chapter of this book https://www.thieme.in/image/catalog/S... Physostigmine and neostigmine are both drugs that affect cholinergic transmission in the body, but they have different properties, uses, and mechanisms of action. 1. Mechanism of Action: Physostigmine: Physostigmine is a reversible acetylcholinesterase inhibitor. Acetylcholinesterase is an enzyme that breaks down acetylcholine, the neurotransmitter responsible for transmitting nerve signals at cholinergic synapses. By inhibiting acetylcholinesterase, physostigmine increases the concentration and duration of acetylcholine at synapses, leading to enhanced cholinergic neurotransmission. Neostigmine: Like physostigmine, neostigmine is also an acetylcholinesterase inhibitor. It works in a similar manner to physostigmine, prolonging the effects of acetylcholine at cholinergic synapses. 2. Clinical Uses: Physostigmine: Physostigmine is primarily used for its effects on the central nervous system and has been employed to reverse the anticholinergic effects of certain drugs, such as atropine and other anticholinergic medications. It is also used in the treatment of glaucoma, as its ability to increase acetylcholine levels can lead to pupil constriction and a reduction in intraocular pressure. Neostigmine: Neostigmine is mainly used to treat conditions related to neuromuscular transmission. It is commonly used to reverse the effects of non-depolarizing neuromuscular blocking agents (used during surgery to induce muscle relaxation) and to manage myasthenia gravis, an autoimmune disorder characterized by muscle weakness and fatigue. 3. Permeability to the Blood-Brain Barrier: Physostigmine: Physostigmine can cross the blood-brain barrier, allowing it to exert its effects in the central nervous system and potentially leading to both therapeutic actions and side effects. Neostigmine: Neostigmine has limited ability to cross the blood-brain barrier, resulting in its primary effects being targeted peripherally, particularly at neuromuscular junctions. 4. Clinical Effects: Physostigmine: The central effects of physostigmine can lead to increased cognitive function, improved memory, and heightened alertness. However, it can also cause side effects such as nausea, vomiting, and headache when used at higher doses. Neostigmine: The main therapeutic effects of neostigmine are related to its ability to enhance neuromuscular transmission. By reversing the effects of neuromuscular blocking agents or improving muscle strength in myasthenia gravis, neostigmine helps restore muscle function. Get in touch with the solution by just clicking the following links- Facebook Group-   / solutionpharamcy   Mobile App - https://play.google.com/store/apps/de... New Channel (Pharmacy Dictionary)    / @pharmacydictionary   E-Mail for official and other work - [email protected] #solutionpharmacy #Pharmacologyclass #Pharmacognosyvideos #GPAT