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Authors: Sureshkumar, A.,1 Payne, M. W.,2,3 Viana, R.,2,3 & Hunter, S. W.1,3,4 1. Faculty of Health Sciences, University of Western Ontario 2. Department of Physical Medicine & Rehabilitation, Parkwood Institute 3. Department of Physical Medicine & Rehabilitation, Schulich School of Medicine & Dentistry, University of Western Ontario 4. School of Physical Therapy, University of Western Ontario Abstract: Background: People 80 years old (oldest old) represent the fastest-growing age group worldwide. Diabetes and peripheral vascular disease are prevalent in this population and responsible for the majority of lower limb amputations (LLAs). Thus, it is predicted that many will undergo an LLA at an advanced age. Successful prosthetic rehabilitation can lead to improved function; however, rehabilitation can be complicated by the presence of multiple comorbidities and other age-related issues. Unfortunately, studies on rehabilitation outcomes for the oldest old LLA are limited. Objectives: 1) To describe changes in patient characteristics stratified by age at admission and discharge for prosthetic rehabilitation over the last 7 years; and 2) To compare rehabilitation outcomes at discharge from prosthetic rehabilitation stratified by age. Proposed Methods: A retrospective chart audit of consecutive admissions (2012 to 2019) to the inpatient amputee program at Parkwood Institute will be conducted. Study criteria are: transtibial level and above, 18 years old. People 80 years old will be matched on gender, etiology and level of amputation to admissions in the age brackets of 50-59, 60-69, and 70-79 years. Outcome measures will be: Montreal Cognitive Assessment (cognition); Timed Up and Go, 2- Minute Walk Test, 6-Minute Walk Test and L-Test (endurance and functional mobility); Activities-specific Balance Confidence scale (fear of falling) and Socket Comfort Score. Outcome measure data will be compared across groups using one-way ANOVA. Future Directions: Investigating the relationship between age and prosthetic rehabilitation outcomes will help clinicians establish prognostic rehabilitation expectations for the oldest old.