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This Harvard Medical School Continuing Education video examines the key question: What are some of the more recent findings on the benefits of exercise? Elizabeth Frates, MD, discusses how exercise benefits the brain by increasing and protecting neurons as well as expanding the volume of the hippocampus to help with cognition. She also highlights the chemical release of irisin during exercise and the role it plays in affecting appetite and protecting against dementia. Dr. Frates is the director of Lifestyle Medicine for the Department of Surgery at Massachusetts General Hospital, and this video is part 5 in the 12-part series: Clinician Wellness. View the playlist: / playlistlist=pl9hncxfz_xynszoam5apqwthcgnn... 00:00 | Brain-derived neurotrophic factor (BDNF) 01:00 | How exercise benefits the hippocampus 01:36 | Findings on irisin release into the body This video was peer reviewed by Dr. Martina McGrath, MB, BCh, FRCPI, PGDip Med Ed, Associate Physician, Brigham and Women’s Hospital, Instructor of Medicine, Harvard Medical School, to validate the quality and accuracy of the content. References: Eustachio Colombo P, Milner J, Scheelbeek PFD, et al. Pathways to "5-a-day": modeling the health impacts and environmental footprints of meeting the target for fruit and vegetable intake in the United Kingdom. Am J Clin Nutr. 2021;114(2):530-539. doi:10.1093/ajcn/nqab076 https://www.ncbi.nlm.nih.gov/pmc/arti... Georgia State University. (2018, January 22). Dietary fiber protects against obesity and metabolic syndrome, study finds. ScienceDaily. Retrieved from www.sciencedaily.com/releases/2018/01/180122184723.htm He FJ, Nowson CA, Lucas M, MacGregor GA. Increased consumption of fruit and vegetables is related to a reduced risk of coronary heart disease: meta-analysis of cohort studies. J Hum Hypertens. 2007;21(9):717-728. doi:10.1038/sj.jhh.1002212 https://core.ac.uk/outputs/13969437 He FJ, Nowson CA, MacGregor GA. Fruit and vegetable consumption and stroke: meta-analysis of cohort studies. Lancet. 2006;367(9507):320-326. doi:10.1016/S0140-6736(06)68069-0 https://pubmed.ncbi.nlm.nih.gov/16443... How Much Sleep Do You Really Need? National Sleep Foundation. October 1, 2020. https://www.thensf.org/how-many-hours... The 7-Minute Workout. The New York Times. https://www.nytimes.com/guides/well/a... Notice: At this time, the content in this video is not accredited.