Sydney Brenner - Enzymologists reject the model of DNA (61/236) скачать в хорошем качестве

Sydney Brenner - Enzymologists reject the model of DNA (61/236)

To hear more of Sydney Brenner’s stories, go to the playlist:    • Sydney Brenner - Coming from Eastern Europ...   South African Sydney Brenner (1927-2019), who jointly discovered messenger RNA, was a pioneer in the field of genetics and molecular biology. He was one of three co-recipients of the 2002 Nobel Prize in Physiology or Medicine. [Listener: Lewis Wolpert; date recorded: 1994] TRANSCRIPT: The model wasn't accepted at all. You see, the… at that stage, you had the establishment. The establishment were all the biochemists, the big guys in… the big men in the world – people like Fritz Lipmann; there were all the people that were… Lynen, you know – all the people doing enzymology. The big man in this country was Tommy Work, who was trying to work on protein synthesis. And I think that this whole idea that you could have a structure which is a theory, that you could go from this theory to something that was biology, that you could do all these things like genetics, they didn't think… and as you know, I mean, Chargaff just said that molecular biologists were people who practised biochemistry without a licence. And in fact I remember one occasion – which was a little later than the period – where Francis had put forward the idea of the adaptor hypothesis. The adaptor hypothesis postulated that for each amino acid there'd be an RNA… well there'd be an adaptor, which we… later became the RNA, and there'd be one enzyme to join the two together. And the biochemists said, 'This is utterly impossible because… that there are going to be 20 enzymes to do this, because had they existed we biochemists would have already have discovered them, and we haven't, so it must be wrong'.