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Since the last update in 2013, what changes have been made to the new guidelines for managing acute coronary syndromes? In this short interview, Dr Sunil Rao (NYU Grossman School of Medicine, New York, US) discusses the new 2025 guideline for the management of acute coronary syndromes released by the AHA and ACC joint committee. The current guideline was informed by a number of clinical trials which focus on improving the outcomes for patients with non-ST segment elevation acute coronary syndrome and ST-segment elevation myocardial infarction. Interview Questions: 1. Can you summarise the main purpose of this updated guideline for the management of acute coronary syndromes? 2. What are the most impactful changes compared to previous guidelines? 3. What strategies can help clinicians incorporate the recommendations into practice? 4. Where do you see the future of guidelines for the management of acute coronary syndromes going? Recorded remotely from New York, 2025. Visit Radcliffe Cardiology: https://www.radcliffecardiology.com/ This content is intended for healthcare professionals only. Radcliffe brings medical knowledge, insight and innovation to life for CV clinicians around the world, using our communications & creative expertise, our platforms and connections across the community to help transform theory into practice faster. Like us on Facebook: / radcliffecardiology Follow us on X: https://x.com/radcliffeCARDIO