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Cancer survivorship is a journey that evolves—physically, emotionally, and socially. This talk from December 10, 2025, explores how embracing variety and adopting a “curious investigator” mindset can support long-term well-being. Centered around the pillars of lifestyle medicine – physical activity, nutrition, social connection, sleep, and stress resilience – we discuss practical ways cancer survivors and thrivers can experiment with new behaviors, adapt routines, and rediscover joy in living well. Participants learn strategies to maintain motivation and foster sustainable health practices that enhance quality of life. Patient guests also share their inspiring stories of how they have incorporated variety to optimize health. This session is part of the PAVING the Path to Wellness Series, a collaboration between Lifestyle Medicine at Mass General Brigham Cancer Institute and the Maxwell & Eleanor Blum Patient and Family Learning Center.