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This dynamic discussion brings together leading scientists to reflect on the critical challenges facing global health research and vaccine development. It focuses on three major challenges in science: public understanding, global collaboration, and inequities in research, particularly in low- and middle-income countries (LMICs). Panelists highlighted practical barriers such as delayed access to reagents, high costs, and bureaucratic obstacles, while emphasizing the need for both rapid, applied research and long-term discovery science. They debated the balance between competition and collaboration, noting that effective solutions often involve partnerships between local scientists and well-resourced international labs. Finally, the conversation underscored the importance of clear science communication, both to the public and policymakers, to ensure trust and informed decision-making during crises. Moderated by: Dr. Jeremy Fry (ProImmune Ltd.) Panellists: Prof. Gene Olinger (University of Texas Medical Branch), Prof. Eng Eong Ooi (Duke-NUS Medical School), Prof. Neelika Malavige (University of Sri Jayawardenepura), Prof. George Fu Gao (Chinese Academy Sciences) and Prof. Eui-Cheol Shin (KAIST)