Azzopardi effect: скачать в хорошем качестве

Azzopardi effect:

This is encrustation of basophilic material around the small blood vessels in certain high grade tumors. Now let me clarify a bit. This phenomenon was initially described by professor John G Azzopardi in small cell carcinoma of lung. Small cell carcinoma of lung which was earlier referred to as oat cell carcinoma, that is composed of primitive appearing cells. These cells are arranged in sheets, clusters or ribbons and are round to oval and they have hyperchromatic nuclei with scant cytoplasm. Nuclear moulding, smudging, atypical mitosis and necrosis are very common. Because of extensive necrosis of these cells, the nuclei disintegrates and subsequently result in release of nucleic acids. These nuclear DNA material gets deposited in the wall of the small blood vessels particularly the capillaries and venules.