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The ISN-KDIGO Webinar on Symptom-Based Complications in Dialysis was recorded on December 5, 2023. The webinar features the Co-Chairs from the KDIGO Symptom-Based Complications in Dialysis Controversies Conference, Raj Mehrotra, MD (United States), and Edwina Brown, MD (United Kingdom). The webinar also features conference attendee and patient, Dawn Edwards (United States). Patients undergoing long-term dialysis report a high burden of symptoms and patients place a high priority on symptom relief. Yet, most symptoms are not recognized by healthcare practitioners and when recognized, are not treated adequately. The KDIGO Controversies Conference on Symptom-Based Complications addressed range of approaches to elicit symptoms, how to prioritize symptoms targeted for relief, shared decision-making to select non-pharmacologic or pharmacologic treatment, and the need for structural changes in care delivery to improve health outcomes. Learning objectives: To understand the burden and consequences of symptoms experienced by patients undergoing long-term dialysis To learn how to engage in shared decision-making to select the treatment approach for symptom relief To understand the structural changes in healthcare delivery needed to mitigate the symptom burden experienced by patients