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In this video, I explain Hemolytic Disease of the Newborn (HDN) in a clear, comparative, and exam-oriented way, using First Aid as the core with integration from Kaplan, Pathoma, and Guyton physiology. 🩸 This lecture focuses on the Kell (KEL) blood group system — the most important minor blood group after ABO and Rh — and compares it side-by-side with Rh and ABO to eliminate common confusions. 🔑 What you will learn in this video: • What is Kell antigen and how it compares to Rh antigen • Why Kell and Rh antigens may be present in some individuals and absent in others • Why anti-Kell and anti-Rh antibodies are NOT naturally occurring • Role of sensitization (pregnancy / transfusion) • Mechanism of HDN: • Rh → RBC destruction • Kell → suppression of erythropoiesis • Why ABO hemolytic disease can occur in the first-born baby • Why Kell and Rh HDN usually affect the second or later pregnancies • High-yield MCQs, clinical correlations, and exam traps 📚 This video is part of my Hematology Integrated Series, designed for: • USMLE / PLAB / FCPS / NRE • Medical students & house officers • Anyone who wants First Aid explained properly with concept integration 🎯 If you understand this video, you will never confuse: • Kell vs Rh • Naturally occurring vs sensitization antibodies • First-born vs subsequent pregnancy HDN #HemolyticDiseaseOfNewborn #HDN #KellBloodGroup #RhIncompatibility #ABOHemolyticDisease #FirstAidUSMLE #USMLE #PLAB #FCPS #NRE #Hematology #HematologySeries #Pathoma #Kaplan #GuytonPhysiology #MedicalEducation #HighYield #ExamPrep #conceptbasedlearning