Unraveling the role of sex in renal ischemia tolerance скачать в хорошем качестве

Unraveling the role of sex in renal ischemia tolerance

Sex-specific differences have been observed in preclinical models of renal ischemic injury. In particular, females recover more readily from ischemia-reperfusion injury (IRI) than males, and testosterone has been shown to have a negative effect on renal ischemia tolerance. The factors that underlie these sex-dependent discrepancies are poorly understood, and it is not clear if these same differences extend to humans. In this episode, Matthew Levine and David Aufhauser describe the development of several murine renal ischemia and transplant models used to evaluate sex-specific effects on recovery after IRI. Their results demonstrate that recipient, not donor, sex determines transplantation outcomes. Moreover, evaluation of patient data from the United Network for Organ Sharing revealed that male recipients had increased delayed graft function compared to female recipients.