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Intrarenal pressure measurement: different way, different result? The advancement of innovative technology in flexible ureteroscope (fURS) and high-power laser system led to expand its indications to deal with more complex upper urinary tract conditions which may lead to higher complication rates. To archive better visibility during procedure, increased fluid irrigation may lead to increased intrarenal pressures (IRP) with potential complications, including infection, pyelovenous backflow, renal damage and fluid absorption. The normal IRP has been shown to be in the range of 0–15 mmHg, pyelovenous backflow and forniceal rupture occurs when IRP rises to 30–50 mmHg. Impact of increased IRPs in perioperative complications and need for IRP monitoring merits attention. The preliminary in vitro, ex vivo and animal studies demonstrated high IRP was associated with irrigation bag pressure, hand-held pump devices, ureteroscope and UAS size. Previously IRP have been measured in patients drained with a nephrostomy tube, which may have affected results. The pilot studies using sensor wires to measure real time IRP during RIRS demonstrated high pressures (200-300 mmHg) were seen during forced irrigation and stone fragmentation. The continuous monitoring of IRP semes to be feasible to identify and avoid high pressure-related complications. The recently developed LithoVueTM Elite System (BostonScientific, Boston, MA, USA) will provide with more information about IRP during RIRS and might contribute to safety. This new device needs to be evaluated.