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Modern interface engineering has evolved from subjective artistic choices into a rigorous hard science rooted in human biology. By treating the human brain as a biological processor with measurable specifications, designers can use mathematical models to predict how users will interact with digital systems. This approach emphasizes that our working memory is restricted to roughly four high-fidelity slots, and exceeding this limit causes critical data to decay. Furthermore, Hick’s Law proves that increasing options creates a bottleneck that slows reaction times, while the economic brain hypothesis suggests we instinctively avoid unnecessary mental effort. To optimize performance, developers must leverage super-capacity by combining sensory inputs and respecting these fixed cognitive constraints. Ultimately, understanding these biological limits is essential for creating safe, efficient interfaces in high-stakes environments like cockpits or operating rooms.