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Future of Huntington’s Disease

Huntington’s disease is a devastating disease that affects many people worldwide. This video provides information about Huntington’s disease as well as its effects, symptoms and signs. The main focus is on future therapeutics to treat Huntington’s and provide information about the treatments that may soon be available. This video was made by McMaster Demystifying Medicine students Karolina Zak, Inna Ushcatz, Komal Noor, and Mahnoor Waseem. Copyright McMaster University 2018 References: 1. Hdsa.org. (2018). What is Huntington's Disease?. [online] Available at: http://hdsa.org/what-is-hd/#genetic [Accessed 19 Mar. 2018]. 2. Huntingtonsociety.ca. (2018). IONIS-HTTRX (RG6042). [online] Available at: https://www.huntingtonsociety.ca/ioni... [Accessed 19 Mar. 2018]. 3. Kumar, A., Kumar Singh, S., Kumar, V., Kumar, D., Agarwal, S. and Rana, M. (2015). Huntington's disease: An update of therapeutic strategies. Gene, [online] 556(2), pp.91-97. Available at: https://journals-scholarsportal-info..... 4. Meera Senthilingam, C. (2018). Huntington's drug trial shows promising results. [online] CNN. Available at: https://www.cnn.com/2017/12/11/health... [Accessed 19 Mar. 2018]. 5. Reference, G. (2018). Huntington disease. [online] Genetics Home Reference. Available at: https://ghr.nlm.nih.gov/condition/hun... [Accessed 19 Mar. 2018]. 6. Reilmann, R., Leavitt, B. and Ross, C. (2014). Diagnostic criteria for Huntington's disease based on natural history. Movement Disorders, [online] 29(11), pp.1335-1341. Available at: https://journals-scholarsportal-info..... 7. Rodrigues, F. and Wild, E. (2017). Clinical Trials Corner: September 2017. Journal of Huntington's Disease, [online] 6(3), pp.255-263. Available at: https://content.iospress.com/articles.... 8. Skotte, N., Southwell, A., Østergaard, M., Carroll, J., Warby, S., Doty, C., Petoukhov, E., Vaid, K., Kordasiewicz, H., Watt, A., Freier, S., Hung, G., Seth, P., Bennett, C., Swayze, E. and Hayden, M. (2014). Allele-Specific Suppression of Mutant Huntingtin Using Antisense Oligonucleotides: Providing a Therapeutic Option for All Huntington Disease Patients. PLoS ONE, [online] 9(9), p.e107434. Available at: http://journals.plos.org/plosone/arti.... 9. Rollnik, J. (2017). Hope for Huntington's disease patients: first clinical gene silencing study in progress. Fortschritte de Neurologie Psychiatrie, [online] 85(8), pp.463-466. Available at: https://www-thieme-connect-de.libacce.... 10. Wild, E. and Tabrizi, S. (2014). Targets for future clinical trials in Huntington's disease: What's in the pipeline?. Movement Disorders, [online] 29(11), pp.1434-1445. Available at: https://onlinelibrary.wiley.com/doi/e....