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From nuanced patient care to emerging molecular pathways, this Medical Grand Rounds will demystify connective tissue disease-associated interstitial lung disease (CTD-ILD) and explore how cutting-edge genetics and clinical insights are converging to shape diagnostics and therapeutics. Through a discussion of early recognition, risk stratification, and personalized treatment strategies, attendees will learn practical tools to inform clinical practice. Speakers: Andrew Gross, MD, is professor and clinical chief of Rheumatology at UCSF Health and co-director of the UCSF Scleroderma Center. Gross works closely with UCSF physicians, immunology researchers, and specialists in the UCSF Interstitial Lung Disease Program to provide comprehensive care to patients with complex conditions. Rupal Shah, MD, MS, is an associate professor and the medical director of adult patient experience in the Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine at UCSF Health. She sees patients on the Lung Transplant and Interstitial Lung Disease services. Shah received the UCSF Exceptional Physician Award in 2022. Anthony Shum, MD, is a professor in the Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine at UCSF Health. His lab recently helped discover the genetic basis of COPA syndrome, an inherited autoimmune disorder that can lead to severe lung and joint disease. Shum also identified a novel lung-specific antigen that is targeted in patients with autoimmune lung disease and demonstrated that autoantibodies to this antigen could be used as a biomarker to detect patients with lung autoimmunity. Program: Allison Bond: Introduction 1:45-8:05 — Rupal Shah, MD, MS 8:05-34:30 — Andrew Gross, MD 34:30-40:15 — Rupal Shah, MD, MS 40:15-56:12 — Anthony Shum, MD 56:12-1:01:08 — Q&A See previous Medical Grand Rounds: April 22: Redefining Mild Aortic Stenosis • • Redefining Mild Aortic Stenosis April 15: Human Reasoning, AI Models, and the Race Toward a Strange New Type of Collaboration • • Human Reasoning, AI Models, and the Race T... April 1: The Path From NIH Funding of Basic Science to New Therapeutics • • The Path From NIH Funding of Basic Science... March 25: More Money, Fewer Problems? Examining Guaranteed Income and Housing Stability • • More Money, Fewer Problems? Examining Guar...