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An Introduction to the Endocannabinoid System

Dr. Daniele Piomelli's keynote address at the Innovations in the Science of Cannabis Conference, May 2022 Dr. Danielle Piomelli, a pioneering figure in cannabis science, takes us on a deep dive into the fascinating world of the endocannabinoid system (ECS). As the Louise Turner Arnold Chair in Neurosciences at UC Irvine and Editor-in-Chief of Cannabis and Cannabinoid Research, Dr. Piomelli shares his extensive knowledge on the history of cannabis, the discovery of THC and CBD, and the intricate mechanisms of the ECS. From the plant's ancient medicinal uses to modern scientific breakthroughs, this talk explores how cannabinoids interact with our bodies, their systemic effects, and their potential therapeutic applications. Whether you're a scientist, medical professional, or simply curious about cannabis, this session offers valuable insights into one of the most complex and misunderstood systems in human biology. Dr. Piomelli also discusses the challenges and opportunities in cannabis research, including the development of cannabinoid-based therapies and the role of terpenes. He addresses common misconceptions, such as the "entourage effect," and highlights the importance of rigorous scientific inquiry in understanding cannabis's full potential. This presentation is a must-watch for anyone interested in the science behind cannabis, its medical applications, and its impact on human health. ______________________________________________________________ 1 Endocannabinoid system explained 2 Cannabis science and research 3 THC and CBD mechanisms 4 Dr. Danielle Piomelli cannabis lecture 5 History of cannabis use 6 Cannabinoid receptors CB1 and CB2 7 Therapeutic uses of cannabis 8 Cannabis and neuroscience 9 Anandamide and 2-AG function 10 Cannabis hyperemesis syndrome 11 Cannabis and pain relief 12 Role of terpenes in cannabis 13 Cannabis and mental health 14 Cannabis research breakthroughs 15 Cannabis and the brain ______________________________________________________________