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Sir, my aunt has been advised by her doctor to undergo a heart transplant. Please explain how safe this procedure is.” In response, Dr. Abhishek Shukla, Geriatrician, explained that a heart transplant is a major and high-risk surgical procedure, as the heart is a vital organ and the only one of its kind in the human body. Therefore, this operation is recommended only in very severe and life-threatening conditions. Dr. Shukla further explained that the most common indication for a heart transplant is dilated cardiomyopathy. In this disease, the muscles of the heart become dilated and weak. Due to this dilation, the heart loses its ability to contract and relax effectively, leading to poor pumping of blood. As a result, patients develop severe symptoms such as extreme weakness, breathlessness even at rest, and inability to walk or perform daily activities. When medical treatment and other surgical options fail, heart transplantation becomes the last life-saving option. He also clarified that a donor heart can be taken only from a brain-dead patient, and strict medical and legal protocols are followed during organ donation. With advances in medical science, the success rate of heart transplantation has improved significantly, though lifelong medicines and regular follow-up are required. Dr. Shukla cited a recent article published in the Times of India about a 51-year-old woman who underwent a heart transplant 25 years ago and is still living a healthy and active life. She had her transplant on 23 January 2000 at the All India Institute of Medical Sciences (AIIMS), New Delhi, performed by a team led by Dr. P. Venugopal, Cardiologist, and Dr. K. K. Talwar, Cardiac Surgeon. This remarkable case shows that although the average survival of a transplanted heart is often quoted as around 5 years, many patients can live much longer with proper care and follow-up