PHARMACOLOGY OF Mitomycin C Mutamycin; Overview, Pharmacokinetics, Use, Effects, Mechanism of action скачать в хорошем качестве

PHARMACOLOGY OF Mitomycin C Mutamycin; Overview, Pharmacokinetics, Use, Effects, Mechanism of action

Mitomycin, also known as mitomycin-C, is an antineoplastic antibiotic used primarily in the treatment of various cancers. Here's an overview of its pharmacology: Mechanism of Action: DNA Cross-Linking: Mitomycin functions as an alkylating agent, causing cross-linking of DNA strands. This inhibits DNA synthesis and function, leading to cell death. Antitumor Activity: It selectively inhibits the synthesis of DNA, and at higher concentrations, it can also suppress RNA and protein synthesis. Pharmacokinetics: Absorption: Mitomycin is administered intravenously, and its pharmacokinetics are not influenced by food. Distribution: It is widely distributed in the body, with a volume of distribution that reflects its extensive tissue penetration. Metabolism: Mitomycin is metabolized in the liver, primarily through reduction and hydrolysis. Excretion: The drug and its metabolites are excreted in both urine and feces. Elimination Half-Life: The elimination half-life is approximately 2 hours, but this can vary based on individual metabolism. Clinical Use: Cancer Treatment: Mitomycin is used to treat various malignancies, including cancers of the lip, oral cavity, pharynx, digestive organs, peritoneum, female breast, and urinary bladder. Glaucoma Surgery: It is also used as an adjunct to eye surgery for the treatment of glaucoma. Upper Tract Urothelial Cancer: Recently, it has been approved for use in low-grade upper tract urothelial cancer (LG-UTUC). Side Effects: Common Side Effects: Bone marrow suppression (thrombocytopenia, leukopenia), nausea, vomiting, and diarrhea. Serious Side Effects: Hemolytic uremic syndrome (HUS), severe neutropenia, and potential for overwhelming infections #Mitomycin