İON 425. Lecture, Copp: Neural Tube Defects 04.03.2024 скачать в хорошем качестве

İON 425. Lecture, Copp: Neural Tube Defects 04.03.2024

Neural tube defects are severe birth defects of the central nervous system that originate during embryogenesis and result from failure of the morphogenetic process of neural tube closure. In higher vertebrates, the neural tube is generated by the processes that shape, bend, and fuse the neural plate, and fusion in the dorsal midline progressively seals the neural tube as it forms. If closure is not completed, the neuroepithelium remains exposed to the environment and consequently subject to degeneration and neuronal deficit. The type and severity of these open neural tube defects vary with the level of the body axis affected. Thus, failure of closure in the prospective brain and spinal cord results in anencephaly and open spina bifida (myelomeningocele), respectively. Once the neural tube has failed to close, ensuing damage to the exposed neural tissue is irreversible, despite possible palliative benefit of in utero surgery. Therefore, primary prevention is the optimal approach for reducing the burden of neural tube defects. Professor Andrew J Copp is giving "Neural Tube Defects" lecture, don't miss it!