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This video describes the difference between psychotic depression and nonpsychotic depression. If we look at the Diagnostic and Statistical Manual (DSM), there is a diagnosis of major depressive disorder (MDD). Within major depressive disorder, there are severity specifiers. One of those specifiers is MDD with psychotic features. This is referred to as psychotic depression and all the other specifiers of MDD would be nonpsychotic depression. About 15% of individuals diagnosed with MDD would qualify as having psychotic depression. In the inpatient population, about 25% of individuals with MDD would have psychotic depression. With psychotic depression there is an elevated risk of the disorder converting into bipolar disorder, particularly if there's an early onset of psychotic depression. Also, relatives of individuals who have psychotic depression have a higher prevalence of bipolar disorder. An individual who has parents with bipolar disorder has an increased risk for psychotic depression, but not for nonpsychotic depression. With psychotic depression, there is an increased depression score overall when compared to nonpsychotic depression.