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One of the reasons mindfulness is becoming mainstream is because it can help us live well in the contemporary world. It is an antidote to busyness and distractedness, however compelling these can be. Many mindfulness practices have been used by people for thousands of years. The science of mindfulness is coming of age. This confluence of ancient and modern is what can give it depth and realism. Mindfulness can be masculine and feminine, it can move in and retreat, it is being strong and vulnerable, ordinary and profound, eminently practical and potentially transformative. Mindfulness skills have extraordinary potential to help us respond to some of the challenges we’re facing in the contemporary world. It can help us understand how we react and behave. It can help us respond with greater wisdom and compassion. This presentation briefly overviews the translational story to date of mindfulness-based cognitive therapy (MBCT). This includes the key milestones over 20 years of definition, theory, innovations in research methods, effectiveness, cost-effectiveness, and implementation. Most importantly, we have learned that MBCT provides a cost-effective approach to helping people to prevent depression and that both can be integrated into mainstream mental health services. But we have also seen a growing evidence base suggesting that MBCT can promote mental health and well-being in the wider population and potentially across the lifespan. How can this work best evolve to meet its full potential? How can we unlock all that we have learned to use these psychological approaches as a vehicle to create a world without the devastating effects of depression, where we enjoy mental health and well-being and are resourced to meet the challenges of the next 50 years? When I say “we,” I mean all of us as individuals, but also as communities and as wider humanity. But for this potential to be realized we need it to be taught and learned well, with solid foundational values and in close dialogue with rigorous science. Willem Kuyken is the Ritblat Professor of Mindfulness and Psychological at the University of Oxford, United Kingdom, and Director of the Oxford Mindfulness Centre. His work has focused on depression across the translational pathway from theory, through treatment and implementation. In particular, his research examines how cognitive therapy and mindfulness-based programs can prevent depression, promote mental health and enhance well-being across the lifespan. Dr. Kuyken has published more than 150 journal articles. He was named by Web of Science as in the top 1% of the most cited scientists in the world in 2019, 2020, 2021 and 2022. Together with Christina Feldman, he wrote Mindfulness – Ancient Wisdom Meets Modern Psychology, published in 2019. A new book for the general population, provisionally entitled Mindfulness for Life is due to be published presently, also with Guilford Press. Published with kind permission from the Speaker.