Serotonin's 5-HT2A Receptor: Neuroological Support for the "Stoned Ape" Theory (Luppi et al., 2024) скачать в хорошем качестве

Serotonin's 5-HT2A Receptor: Neuroological Support for the "Stoned Ape" Theory (Luppi et al., 2024)

This video explores Luppi et al's 2024 publication "A Role for the Serotonin 2A Receptor in the Expansion & Functioning of the Human Transmodal Cortex." I. Introduction • This video explores the role of serotonin's 5-HT2A recptor in driving: (A) Human Brain Development (across the lifespan). (B) Human Brain Expansion (across evolution). • We will follow Luppi et al's 2023 publication (full citation below). • We will explore genetic, evolution, & neuroscience data focussing on: (A) How the 5-HT2A receptor shapes human cognition & consciousness. (B) The role of the Transmodal Cortex in Human Consciousness. (C) Scientific data supporting the "Stoned Ape Theory." (D) Impact of Hominin Psilocybin Consumption on Brain Evolution. II. Cortical Expansion & Serotonin's 5-HT2A Receptor (5-HT2AR) • The human transmodal cortex expanded disproportionately in evolution. • This expansion supports high-order cognition and social behavior. • 5-HT2A receptors are most dense in these expanded cortical regions. • They stimulate the proliferation of basal progenitor cells. III. Evolutionary Fenetics • The 5-HT2B receptor gene is nested within a proteasome subunit gene. • This pairing appears in pre-vertebrates and is highly conserved. • 5-HT2B may be the ancestor of the 5-HT2A and 5-HT2C subtypes. • Gene duplications allowed 5-HT2A to specialize in cortical function. IV. Neuroplasticity & Flexibility (5-HT2A) • 5-HT2A activation promotes structural and functional plasticity. • It enables the brain to escape rigid patterns and adapt to stress. • Psychedelics harness this mechanism to enhance cognitive flexibility. • This creates a "pivotal mental state" for rapid learning and change. V. From Ancient Origins to Modern Minds • Serotonin began as an antioxidant in single-celled organisms. • It evolved to regulate morphology and movement in plants and animals. • In humans, it acts as a homeostatic regulator of mind and body. • The 5-HT2A receptor is the key to this evolutionary journey. VI. Therapeutic Implications • Understanding this receptor opens new paths for treating mental illness. • Psychedelics may reopen critical periods for social reward learning. • They can reduce the hierarchical differentiation of brain networks. • This offers hope for conditions like depression and addiction. VII. Additional resource support • See NourishED RFI's NotebookLM Resource Support Page. • https://notebooklm.google.com/noteboo... VIII. Source Luppi, A. I., Girn, M., Rosas, F. E., Timmermann, C., Roseman, L., Erritzoe, D., Nutt, D. J., Stamatakis, E. A., Spreng, R. N., Xing, L., Huttner, W. B., & Carhart-Harris, R. L. (2023). A role for the serotonin 2A receptor in the expansion and functioning of human transmodal cortex. Brain. https://doi.org/10.1093/brain/awad311 #neuroscience #evolution #serotonin #brainhealth #psychedelics #neuroplasticity #genetics #corticalexpansion #humanbrain #scienceeducation #psychedelicresearch #psychedelicscience #stonedape #stonedapetheory #REBUS ‪@NIMHgov‬ ‪@NIHgov‬ ‪@NIHVideoCast‬ ‪@NIH_NCCIH‬ ‪@BBRFoundation‬ ‪@naropauniversity‬ ‪@nunmedu‬ ‪@naropaallianceforpsychedel7015‬ ‪@TheStonedApes‬ ‪@stonedapetheoryofficial8546‬ ‪@Carhartharrislab‬ ‪@consciousnessevolution1111‬ ‪@accessconsciousness‬ ‪@ConsciousnessResearch‬ ‪@DrKahbsingh‬ ‪@ecr-existentialconsciousne2156‬ ‪@consciousnessresearchnetwo3817‬ ‪@Psychedelic‬ ‪@PortlandPsychedelicSociety‬ ‪@psychedelicsupport‬ ‪@psychedelicsomatic‬ ‪@yalepsychedelicsciencegrou9534‬ ‪@stanfordpsychedelicscience12‬ ‪@OxfordPsychedelicSociety‬ ‪@mghcenterfortheneuroscienc28‬ ‪@UCBCSP‬