The cutting edge of anti-ageing science | Venki Ramakrishnan скачать в хорошем качестве

The cutting edge of anti-ageing science | Venki Ramakrishnan

Molecular biologist and Nobel Prize winner Venki Ramakrishnan discusses his new book, Why We Die: The New Science of Aging and the Quest for Immortality. Venki and host Luisa Rodriguez cover: • What we can learn about extending human lifespan — if anything — from “immortal” aquatic animal species, cloned sheep, and the oldest people to have ever lived. • Which areas of anti-ageing research seem most promising to Venki — including caloric restriction, removing senescent cells, cellular reprogramming, and Yamanaka factors — and which Venki thinks are overhyped. • Why eliminating major age-related diseases might only extend average lifespan by 15 years. • The social impacts of extending healthspan or lifespan in an ageing population — including the potential danger of massively increasing inequality if some people can access life-extension interventions while others can’t. • And plenty more. Learn more and see the full transcript on the 80,000 Hours website: https://80000hours.org/podcast/episod... Chapters: • Cold open (00:00:00) • Luisa's intro (00:01:04) • The interview begins (00:02:21) • Reasons to explore why we age and die (00:02:35) • Evolutionary pressures and animals that don't biologically age (00:06:55) • Why does ageing cause us to die? (00:12:24) • Is there a hard limit to the human lifespan? (00:17:11) • Evolutionary tradeoffs between fitness and longevity (00:21:01) • How ageing resets with every generation, and what we can learn from clones (00:23:48) • Younger blood (00:31:20) • Freezing cells, organs, and bodies (00:36:47) • Are the goals of anti-ageing research even realistic? (00:43:44) • Dementia (00:49:52) • Senescence (01:01:58) • Caloric restriction and metabolic pathways (01:11:45) • Yamanaka factors (01:34:07) • Cancer (01:47:44) • Mitochondrial dysfunction (01:58:40) • Population effects of extended lifespan (02:06:12) • Could increased longevity increase inequality? (02:11:48) • What’s surprised Venki about this research (02:16:06) ---- The 80,000 Hours Podcast features unusually in-depth conversations about the world’s most pressing problems and what you can do to solve them.