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Here Dr Sorrentino discusses mitochondria and muscle aging and results from trials of Urolithin A and NR in countering some of the ill effects. Some links are affiliate links so we will earn a commission when they are used to purchase products. ProHealth 15% discount Code MODERN : https://prohealth.pxf.io/zNOPoW NMN https://prohealth.pxf.io/DKeEmd Renue By Science 10% : Code MHS https://tinyurl.com/35jyuk33, NMN https://tinyurl.com/ys4hxwyf DoNotAge 10% discount code MHS https://tinyurl.com/6dbvhv87 Pure NMN https://tinyurl.com/wyzj2f3d Momentous Supplements 15% discount Code MHS https://momentous.go2cloud.org/SH2s Oxford Healthspan Primeadine Spermidine supplements: 15% discount Code MHS https://tinyurl.com/28admfxr Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN NMN Bio 10% off all products https://tinyurl.com/2af2v2fw Code ModernHealthSpan10 in link Pure Clean Performance 15% Discount Code: MODERNHEALTH15 http://tinyurl.com/msspanpw Fundaminos, Essential Amino Acids : http://tinyurl.com/m579tvrw ☕If you would like to support our channel, we’d love a coffee…thank you! https://www.buymeacoffee.com/mhealthspan NOVOS Core & Boost https://novos.sjv.io/QyWP7o code 5OFFMHS Insidetracker 20% discount Code MODERN20 https://insidetracker.sjv.io/NkbP7V Bulletproof 15% off with coupon code: HEALTHSPAN15: https://tinyurl.com/4npjk5vp SiPhox Health 20 % Code MODERN blood test (only in US & Canada) https://siphoxhealth.com/discount/modern OmegaQuant 5% discount Code MODERN https://omegaquant.com/shop/ ⏲️Chapters 00:00 Aging mitochondria 03:00 How to encourage mitophagy 04:50 Sarcopenia 07:30 Protein aggregates in sarcopenia 08:15 NR ameliorates protein aggregation 12:40 Exercise & protein build up 🌐Links in this video Dr Sorrentino's page at NUS https://medicine.nus.edu.sg/bch/facul... Vincenzo Sorrentino is an Italian-born scientist in the fields of aging, mitochondrial biology and neuromuscular degeneration. He obtained his PhD Cum Laude at the University of Amsterdam on LDL-cholesterol regulation by the ubiquitin-proteasome system. Subsequently, he moved to Lausanne, Switzerland, for his postdoctoral research in Prof. Johan Auwerx’s lab at the EPFL. His work there focused on the understanding of mitochondria and NAD+ metabolism in neurodegeneration and muscle aging. He then obtained a position as Group Leader at the Nestlé Institute of Health Sciences in Lausanne, to lead research focused on integrating basic discoveries on nutraceuticals and their effects on mitochondria and protein homeostasis with their translation into novel clinical applications. Since December 2022, he is an Assistant Professor at the NUS with the Dept. of Biochemistry and the Healthy Longevity TRP, Yong Loo Lin School of Medicine, to continue to develop his research on how metabolism, nutrition and proteostasis are linked and impact on health and aging. *************************************** Health claims Disclosure: Information provided on this video is not a substitute for direct, individual medical treatment or advice. Please consult with your doctor first. Products or services mentioned in this video are not a recommendation. Audio Copyright Disclaimer Please note that we have full authorization to the music that we used in our videos as they were created using the service WeVideo which provides the rights to the music. The rights are detailed in the terms of use that can be reviewed here https://www.wevideo.com/terms-of-use and any following inquiries should be addressed to [email protected]. ************************************************** 📖Books Dr Peter Attia Outlive: The Science and Art of Longevity - https://amzn.to/472lu68 Dr David Sinclair Lifespan Book – https://amzn.to/2MESFVb Dr Sandra Kaufmann The Kaufmann Protocol: Aging Solutions https://amzn.to/3Typ41x The Kaufmann Protocol: Why we Age and How to Stop it https://amzn.to/3yWnEEo Dr Steven Gundry - Unlocking the Keto Code - https://amzn.to/3ID7pi4 The Longevity Paradox - https://amzn.to/3q7t2nC The Plant Paradox - https://amzn.to/3Q9E32j Dr Mary Newport Clearly Keto: For Healthy Brain Aging and Alzheimer’s Prevention https://amzn.to/3XRhKih The Complete Book of Ketones: A Practical Guide to Ketogenic Diets and Ketone Supplements https://amzn.to/4008cmX #NAD #NR #urolithinA