43: Reproductive System and Glycation with Dr. Paul Reynolds скачать в хорошем качестве

43: Reproductive System and Glycation with Dr. Paul Reynolds

In this episode of the College of Glycation, Dr. Paul Reynolds—Professor of Cell Biology—examines one of the most metabolically sensitive systems in the human body: the reproductive system. Fertility, hormonal balance, vascular function, and even the health of future generations are all deeply influenced by metabolic chemistry. And when glycation accelerates, reproductive health is often one of the first systems to suffer. Glycation is a non-enzymatic reaction in which sugars like glucose and fructose bind to proteins and lipids, forming advanced glycation end products (AGEs). These sticky, inflammatory molecules accumulate in tissues over time, cross-link structural proteins, and activate the AGE–RAGE inflammatory pathway. The result is oxidative stress, endothelial dysfunction, hormonal disruption, and impaired cellular signaling—exactly the processes reproductive function depends on. This lecture explores how glycation disrupts both female and male reproductive physiology. In women, Dr. Reynolds explains how AGEs accumulate in ovarian tissue, interfere with steroid hormone production, promote fibrosis, and contribute to conditions like polycystic ovary syndrome (PCOS). You’ll learn how insulin resistance—even without overt diabetes—can elevate AGE levels and disrupt ovulation, and how dietary AGE reduction has been shown to improve hormonal and metabolic markers in women with PCOS. In men, the focus turns to erectile dysfunction as an early warning sign of vascular and metabolic disease. Because erections depend on nitric oxide and healthy endothelial function, AGE accumulation in penile tissue stiffens collagen, impairs nitric oxide signaling, damages small vessel supply to nerves, and makes standard treatments less effective. The episode then shifts to pregnancy and the concept of metabolic memory. Elevated blood sugar and AGE accumulation during gestation contribute to placental dysfunction, preeclampsia, gestational diabetes, and altered fetal development. Emerging research suggests that high maternal AGE exposure may influence ovarian function, metabolic health, and insulin sensitivity in offspring—highlighting the possibility of transgenerational metabolic programming. Backed by peer-reviewed research, this episode connects cellular biochemistry to fertility, sexual function, pregnancy outcomes, and long-term health. The message is clear: reproductive health is not isolated from metabolism—it reflects it. Topics Covered -What glycation is and how AGEs form -AGE–RAGE signaling and inflammatory cascades -PCOS, insulin resistance, and ovarian AGE accumulation -Collagen cross-linking and ovarian fibrosis -Erectile dysfunction and nitric oxide impairment -Vascular and nerve damage from glycation -Gestational diabetes and placental dysfunction -Transgenerational metabolic programming -Metabolic memory and long-lived AGE damage -Practical strategies to reduce glycation burden If you're interested in fertility, hormonal health, pregnancy, metabolic disease, or the biochemistry of aging, this episode reveals how deeply reproductive function depends on metabolic integrity—and why protecting your metabolism protects future generations. About Dr. Paul Reynolds Dr. Reynolds is a biomedical scientist and professor at Brigham Young University, known for translating complex physiology into clear, practical insights. The College of Glycation series explores how metabolic chemistry shapes aging, chronic disease, and organ system health. #Glycation #ReproductiveHealth #PCOS #Fertility #InsulinResistance #MetabolicHealth #AGEs #CollegeOfGlycation #Hormones #HealthyAging Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3 Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition (code Paul10 for 10% off): https://cleanformnutrition.com/produc... Paul’s favorite allulose source: https://rxsugar.com (discount PAUL20) Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount DRPAUL for 50% off labs and smart supplements, 15% off all other products)