Dr. Kapil Bharti delivers the 12th Sayer Vision Research Lecture скачать в хорошем качестве

Dr. Kapil Bharti delivers the 12th Sayer Vision Research Lecture

On May 26, 2021 at 11:30 a.m. – Kapil Bharti, Ph.D., senior investigator and chief of the Ocular and Stem Cell Translational Research Section at the National Eye Institute, delivered the 12th Sayer Vision Research lecture. In his talk, titled “Translating Human Retinal Pigment Epithelium (RPE) Biology into Disease Treatments using Induced Pluripotent Stem Cells” Bharti summarized his team’s development of a therapy for age-related macular degeneration (AMD), a leading cause of vision loss in people age 65 and older. The stem cell-based therapy hinges on Bharti’s technique to produce replacement patches of RPE, a monolayer of cells in the back of the eye that maintains the integrity of the light-sensing photoreceptors and that fails in AMD. Construction of a patch begins with an AMD patient’s blood cells, which are then induced into pluripotent stem cells and then RPE cells. The cells are grown on a biodegradable scaffold to form the patch. Once the RPE cells are functionally mature, the patch is implanted into the retina using novel surgical tools developed by Bharti’s team. In animal studies the lab-created patch rescued photoreceptors and vision. In late 2019, Bharti’s team secured approval from the U.S. Food and Drug Administration for a phase I/IIa clinical trial testing the safety and feasibility of the patch in AMD patients. As part of the federal government’s National Institutes of Health (NIH), the National Eye Institute’s mission is to “eliminate vision loss and improve quality of life through vision research.” Learn more about NEI at https://nei.nih.gov Twitter:   / nateyeinstitute   LinkedIn:   / national-eye-institute-nei   Facebook:   / nationaleyeinstitute   For information on privacy policy and disclaimer, visit: https://www.nei.nih.gov/web-policies/...