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A Battle of Antihistamines: First Generation vs Second Generation Antihistamines

Seasonal allergies can be treated with over-the-counter allergy medications, such as Benadryl and Claritin. However, these common brands can be classified into two types of drugs: 1st generation and 2nd generation antihistamines, each with different characteristics. Here, we introduce antihistamines (allergy medications) and break down the two types to help you make informed decisions for your next trip to the pharmacy. This video was made by McMaster University students Fayth Frank, Kimberly Fung, Jasnoor Ghuman, and Abbas Hassanali in collaboration with the Demystifying Medicine McMaster Program. This video is provided for general and educational information only. Please consult your health care provider for information about your health. Copyright McMaster University 2024 References: Cleveland Clinic. (2020, July 13). Antihistamines: Definition, types & side effects. https://my.clevelandclinic.org/health... Golightly, L. K., Greos, L. S. (2005). Second-generation antihistamines: Actions and ffficacy in the management of allergic disorders. Drugs, 65(3), 341-384. https://doi.org/10.2165/00003495-2005... Joh, H., Kwon, H., Son, K. Y., Yun, J. M., Cho, S. H., Han, K., Park, J., Cho, B. (2022). Allergic diseases and risk of incident dementia and Alzheimer’s Disease. Annals of Neurology, 93(2), 384-397. https://doi-org.libaccess.lib.mcmaste... Kalpaklioglu, F., Baccioglu, A. (2012). Efficacy and safety of H1-Antihistamines: An update. Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 11(3), 230-237. https://doi.org/10.2174/1871523128041... Kay, G. G. (2000). The effects of antihistamines on cognition and performance. Journal of Allergy and Clinical Immunology, 105(6), S622-S627. https://doi.org/10.1067/mai.2000.106153 Sánchez-Borges, M., Ansotegui, I. J. (2019). Second generation antihistamines: An update. Current Opinion in Allergy and Clinical Immunology, 19(4), 358-364. https://doi.org/10.1097/ACI.000000000... Simons, F. E., & Simons, K. J. (2008). H1 antihistamines: current status and future directions. The World Allergy Organization journal, 1(9), 145–155. https://doi.org/10.1186/1939-4551-1-9... Wolfson, A. R., Wong, D., Abrams, E. M., Waserman, S., & Sussman, G. L. (2022). Diphenhydramine: time to move on?. The Journal of Allergy and Clinical Immunology: In Practice, 10(12), 3124–3130.