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According to the University of Chicago Celiac Disease Center, 10% of MS patients also suffer from celiac disease. Studies conducted in Italy and Spain uncovered a significant increased prevalence of celiac disease in first-degree relatives of MS patients, 18% and 32% respectively. Additional research has identified situations in which celiac disease mimicked other neurological disorders such as MS and ALS. With evidence like that, it is definitely worth it to further explore the relationship between MS and celiac disease. Today, the Gluten Free RN investigates whether MS and celiac disease are similar, related, or perhaps the same thing, as she shares case studies from the literature and her own experience. Nadine discusses the story of Dr. Terry Wahls, explaining how she was able to resolve her symptoms of MS with a variation of a Paleo diet. She outlines the analogous symptoms of MS and celiac cerebellar ataxia, the neurological damage caused by gluten, and how malabsorption of nutrients caused by intestinal damage can extend to medication. Listen and learn how Nadine and others have resolved symptoms of MS and other neurological disorders on a gluten-free diet! What’s Discussed: Nadine’s MS scare Bouts with falling, dragging feet Numbness, tingling (neuropathy) Symptoms disappeared after adopting gluten-free diet Takes two to three years to resolve neurological symptoms Dr. Terry Wahls’ story Diagnosed with MS, confined to wheelchair Continued to research condition Adopted version of Paleo diet Now walks without cane, rides bike again Conducts seminars to share how healed mitochondria The commonalities between celiac disease and MS Both autoimmune issues Studies necessary to determine if conditions are similar, related, or the same How celiac disease affects the body Triggered by ingestion of gluten Causes villous atrophy, cryptic hyperplasia in small intestines, damage to immune system Primarily neurological disorder The symptoms of celiac cerebellar ataxia Poor balance Hard to distinguish where body is in space Trip, stumble or fall Related to vision The multi-organ manifestations of celiac disease in the central nervous system White matter lesions Inflammatory cerebral spinal fluid syndrome Sinus venous thrombosis Epilepsy, seizure disorders Cerebellar pontine atrophy Encephalopathy Myelopathy Dementia Gluten ataxia Migraines, headaches Depression, anxiety Cerebellar ataxia Nadine’s patient who wasn’t responding to MS medication Nadine recommended celiac testing Panel negative, but gene carrier Already adopted gluten-free diet Fewer medications necessary Hope to decrease, discontinue meds Malabsorption issues extend to medications, could stem from undiagnosed celiac disease The 2014 study in Vienna regarding celiac disease and MS Concluded that celiac disease may mimic MS Celiac disease may be present despite absence of anti-gliadin antibodies If patient history indicates gastrointestinal issues, celiac disease should be considered even if CSF and MRI findings suggest MS The new evidence around seronegativity in celiac disease Most labs only test for tissue transglutaminase 2 Transglutaminase 6 is specific for neurological damage caused by gluten The 2014 Italian study of the genetic overlap between celiac disease and MS Sites significant increased prevalence of celiac disease in MS first-degree relatives (18%) Recommends celiac testing in MS patients who aren’t responding to MS treatment or present with ataxia The association between MS and celiac disease as reported by the University of Chicago Celiac Disease Center Approximately 10% of those who have MS also have celiac disease The genes that indicate a predisposition to celiac disease HLA-DQ2 HLA-DQ8 The 2013 Iranian case study of a celiac patient diagnosed with MS 37-year-old woman with history of chronic abdominal pain Diagnosed with celiac disease, adopted gluten-free diet Became ataxic, met with neurologist MRI indicated multiple sclerosis Nadine argues that patient likely re-exposed to gluten How gluten acts as a neurotoxin Pastor exposed to gluten in cookies had acute neurological event Shaking, tremors (similar to stroke) The 2007 Oxford case study of celiac disease mimicking ALS 44-year-old man with progressive right-sided spastic hemiparesis (muscle wasting) Remote family history of celiac disease Strict gluten-free diet resolved most symptoms Why patients with neurological symptoms should be tested for celiac disease The anti-gliadin antibody is excellent biomarker for gluten sensitivity Why it is acceptable to adopt a gluten-free diet if your antibody test is negative for celiac disease The Paleo diet Nadine suggests for celiac and gluten-sensitive patients Gluten-, dairy-free Whole food Low carb, super-good high fat The increased prevalence of celiac disease in MS patients revealed in a 2011 study ...